Anti-CCR5 Antibody, Non-Fucosylated (CAT#: BioBet-635ZP) Datasheet

CCR5

chemokine (C-C motif) receptor 5 (gene/pseudogene)

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.

CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; HGS004, CCR5 mab, CCR5mAb004

Plasma membrane

Diseases associated with CCR5 include West Nile Virus and Diabetes Mellitus, Insulin-Dependent, 22.

Its related pathways are Signaling by GPCR and AKT Siganaling Pathway.

Many inflammatory cc chemokines of the receptor, including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES, then transduce signals by increasing intracellular calcium levels. May play a role in controlling the proliferation or differentiation of the granulocyte lineage.

Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody; Signaling Transduction antibody

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4

BioBet-635ZP

Human

Human

HGS004 is a human immunoglobulin (Ig) G4 monoclonal antibody against CCR5. HGS004 binds to and inhibits the activity of the CCR5 receptor on the cell surface. HIV uses both the CCR5 and the CD4 receptors to gain entry to the cell, but CCR5 is the primary receptor enabling HIV transmission and replication from the early stages of infection through to progression to AIDS.

HIV Infection

HIV Infection