Anti-CCL21 Antibody, Non-Fucosylated (BioBet-631ZP) (CAT#: BioBet-631ZP) Datasheet

CCL21

chemokine (C-C motif) ligand 21

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

CCL21; chemokine (C-C motif) ligand 21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21; C-C motif chemokine 21; beta chemokine exodus-2; secondary lymphoid tissue chemokine; Efficient Chemoattractant for Lymphocytes; small inducible cytokine subfamily A (Cys-Cys), member 21

Extracellular region or secreted

Diseases associated with CCL21 include Gastric Lymphoma and Sjogren Syndrome.

Its related pathways are Signaling by GPCR and PEDF Induced Signaling.

Inhibit hematopoiesis and stimulate chemotaxis. Chemotaxis in vitro is ineffective against thymocytes and activated T cells, but not against b cells, macrophages or neutrophils. Shows preferential activity on naive T cells. May play a role in mediating the homing of lymphocytes to secondary lymphoid organs. Binds to the atypical chemokine receptor ACKR4 and mediates the recruitment of -arrestin (ARRB1/2) to ACKR4.

1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MOR08389

Human

Human

The antibody binding to human CCL21 (hCCL21) can be used in the treatment and/or prevention of human diseases and disorders, particularly those of a fibrotic nature.

Inflammatory Diseases

Inflammatory Diseases