Description
Anti-Cathepsin S Antibody, Non-Fucosylated (BioBet-753ZP) is a human monoclonal IgG antibody against Cathepsin S. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Colorectal Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cathepsin S antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CTSS
Full Name
cathepsin S
Background
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
CTSS; cathepsin S
Gene ID
1520
UniProt ID
Q8WTT0
Cellular Localization
Extracellular region or secreted, Lysosome
Involvement in Disease
Diseases associated with CTSS include Dacryoadenitis.
Related Pathways
Its related pathways are Lysosome and Degradation of the extracellular matrix.
Function
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Post-translational modifications
1.Glycosylation at Asn104 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Fsn0503h
Description
Fsn0503h is a fully human anti-Cathepsin S antibody with anti-tumour and anti-angiogenic properties. Cathepsin S is a cysteine protease highly expressed in many cancers including colorectal, breast, prostate and glioblastoma's. It is involved in tumour progression through extracellular matrix remodelling. Fusion Therapeutics has generated positive preclinical data demonstrating efficacy of Fsn0503h in multiple models both as a monotherapy and in combination with approved agents.
Antibody Indication
Colorectal Cancer
