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Anti-Carbonic Anhydrase XII Antibody, Non-Fucosylated (6A10) (CAT#: BioBet-618ZP) Datasheet

Target
Carbonic Anhydrase XII
Isotype
IgG2a
Description
Anti-Carbonic Anhydrase XII Antibody, Non-Fucosylated (BioBet-618ZP) is a Rat monoclonal IgG2a antibody against Carbonic Anhydrase XII. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Carbonic Anhydrase XII antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CA12
Full Name
carbonic anhydrase XII
Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.
Alternative Names
CA12; carbonic anhydrase XII; CAXII; HsT18816; carbonic anhydrase 12; CA-XII; carbonic dehydratase; carbonate dehydratase XII; tumor antigen HOM-RCC-3.1.3
Gene ID
771
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CA12 include Hyperchlorhidrosis, Isolated and Degenerative Disc Disease.
Related Pathways
Its related pathways are Celecoxib Pathway, Pharmacodynamics and Metabolism.
Function
Reversible hydration of carbon dioxide.
Field of research
Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody
Post-translational modifications
Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2a
Antibody Clone
6A10
Host
Rat
Species Reactivity
Human
Description
6A10 is the first CA XII-specific inhibitory monoclonal antibody, offered an opportunity to evaluate this strategy with regard to CA XII-mediated catalysis. 6A10 inhibited exofacial CA activity in CA XII-expressing cancer cells.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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