Anti-CADM1 Antibody, Non-Fucosylated (BioBet-621ZP) (CAT#: BioBet-621ZP) Datasheet

CADM1

cell adhesion molecule 1

CADM1; cell adhesion molecule 1; BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1; TSLC-1; nectin-like 2; nectin-like protein 2; truncated CADM1 protein; TSLC1/Nectin-like 2/IGSF4; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1; immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; spermatogenic immunoglobulin superfamily; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2

Plasma membrane

Diseases associated with CADM1 include Retroperitoneal Fibrosis and Acute Myeloid Leukemia With T(9;11)(P22;Q23).

Its related pathways are Cell junction organization and Cell adhesion molecules (CAMs).

Mediates homophilic cell adhesion in a Ca(2+)-independent manner. It also mediates heterophilic cell-cell adhesion to CADM3 and NECTIN3 in a Ca(2+)-independent manner (through similarity). The interaction with CRTAM promotes the cytotoxicity of natural killer (NK) cells and the secretion of interferon-gamma (ifn-gamma) by CD8+ cells in vitro, and NK cell-mediated rejection of CADM1-expressing tumors in vivo. In mast cells, it can mediate connections with nerves and promote communication with nerves. CADM1 and MITF are essential for the development and survival of mast cells in the body. By interacting with CRTAM, it promotes the adhesion of CD8+ t cells to CD8+ dendritic cells and regulates the retention of activated CD8+ t cells in draining lymph nodes (by similarity). The intestine maintains intraepithelial CD4+ CD8+ t cells, as well as intraepithelial and lamina propria CD8+ t cells and CD4+ t cells (similar). The interaction with CRTAM promotes the adhesion of CD103+ dendritic cells associated with the intestine, which may promote intestinal homing and the expression of adhesion molecules on t cells, and promote the development of CD4+ t cells to CD4+ CD8+ t cells The transformation (similarity). As a synaptic cell adhesion molecule, it participates in the formation of dendritic spines and synapse assembly (through similarity). May be involved in neuron migration, axon growth, pathfinding, and formation of nerve bundles on axons of differentiated neurons (through similarity). They play different roles in the adhesion of spermatocytes and sperm cells to supporting cells and their normal differentiation into mature sperm (through similarity). Play a tumor suppressor effect in non-small cell lung cancer (NSCLC) cells. May contribute to lepidic's low-invasive phenotype of tumor cells.

Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-621ZP

Human

Human

The monoclonal antibody specifically bind to CADM1 with high affinity are used for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

Cancer

Cancer