Anti-Cadherin-2 Antibody, Non-Fucosylated (BioBet-696ZP) (CAT#: BioBet-696ZP) Datasheet

CDH2

cadherin 2, type 1, N-cadherin (neuronal)

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

CDH2; cadherin 2, type 1, N-cadherin (neuronal); cadherin 2; cadherin-2; CDHN; NCAD; CD325; CDw32

Plasma membrane

Diseases associated with CDH2 include Corpus Callosum, Agenesis Of and Arrhythmogenic Right Ventricular Cardiomyopathy.

Its related pathways are Neural Crest Differentiation and Mesenchymal Stem Cells and Lineage-specific Markers.

Calcium-dependent cell adhesion protein; it preferentially mediates the adhesion of homotypic cells by dimerizing with the CDH2 chain of another cell. Cadherin may therefore help the classification of heterogeneous cell types. As a regulator of neural stem cell quiescence, it mediates the anchoring of neural stem cells and ependymal cells in the adult subependymal zone: When MMP24 is lysed, cdh2-mediated anchoring is affected, thereby regulating the quiescence of neural stem cells. CDH2 may be involved in neural recognition mechanisms. In hippocampal neurons, dendritic spine density may be regulated.

Neuroscience antibody; Signaling Transduction antibody

Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity). May be phosphorylated by OBSCN.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-696ZP

Human

Human

This is a fully human antibody against N-Cadherin for therapeutic and diagnostic methods in cancer.

Cancer

Cancer