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Anti-C5 Eculizumab Antibody, a Fc Silent Biobetter (CAT#: FCS-086P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human IgG2 / G4, κ
Clone Number
Eculizumab
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
C5
Official Name
C5
Alternative Names
Eculizumab; soliris; 219685-50-4; h5G1.1; DB01257 C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298;
Gene ID
727
Uniprot ID
P01031

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All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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