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Anti-C-X-C motif chemokine 10 Fc Silent Antibody (FCS-183P) (CAT#: FCS-183P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human Therapeutic Antibody
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
C-X-C motif chemokine 10
Official Name
CXCL10
Full Name
C-X-C Motif Chemokine Ligand 10
Background
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene.
Diseases associated with CXCL10 include Endotheliitis and Paracoccidioidomycosis.
Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system.
Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity.
An important paralog of this gene is CXCL9.
Alternative Names
CXCL10; chemokine (C-X-C motif) ligand 10;INP10; SCYB10; small inducible cytokine subfamily B (Cys X Cys); member 10;C-X-C motif chemokine 10;C7;crg 2;gIP 10;IFI10;IP 10;mob 1;gamma IP10;gamma-IP10;small-inducible
Gene ID
3627
Uniprot ID
P02778

All products and services are for Research Use Only. Do Not use in humans.

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