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Anti-Bv8 Antibody, Non-Fucosylated (BioBet-1570ZP) (CAT#: BioBet-1570ZP) Datasheet

Target
Bv8
Isotype
IgG
Description
ADCC-Enhanced anti-Bv8 (h2G9.K4G1.v55) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Bv8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PROK2
Full Name
prokineticin 2
Background
This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
PROK2; prokineticin 2; BV8; HH4; PK2; KAL4; MIT1; Bv8
Gene ID
60675
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with PROK2 include Hypogonadotropic Hypogonadism 4 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
It can be used as the output molecule of the suprachiasmatic nucleus (SCN) to transmit the circadian rhythm of behavior. It can also be output synchronously with the SCN in the local function. Can effectively contract gastrointestinal smooth muscle.
Post-translational modifications
No Post-translational modifications
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
h2G9.K4G1.v55
Host
Humanized
Species Reactivity
Human
Description
The anti-Bv8 antibody is a monoclonal antibody which targets Bv8. And it can be used as a pharmaceutical composition for the prevention or treatment of cancer.
Antibody Indication
Cancer

Cancer

Related Products

Anti-Bv8 Antibody, Non-Fucosylated (BioBet-1571ZP) (CAT#: BioBet-1571ZP)
Anti-Bv8 Antibody, Non-Fucosylated (BioBet-1569ZP) (CAT#: BioBet-1569ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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