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Anti-BST1 Antibody, Non-Fucosylated (BioBet-607ZP) (CAT#: BioBet-607ZP) Datasheet

Target
BST1
Isotype
IgG
Description
Anti-BST1 Antibody, Non-Fucosylated (BioBet-607ZP) is a human monoclonal IgG antibody against BST1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BST1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BST1
Full Name
bone marrow stromal cell antigen 1
Background
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.
Alternative Names
BST1; bone marrow stromal cell antigen 1; CD15
Gene ID
683
UniProt ID
Q10588
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with BST1 include Paroxysmal Nocturnal Hemoglobinuria and Rheumatoid Arthritis.
Related Pathways
Its related pathways are Metabolism of proteins and Metabolism of water-soluble vitamins and cofactors.
Function
Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Field of research
Immune System antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn66, Asn95, Asn148, and Asn192 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-607ZP
Host
Human
Species Reactivity
Human
Description
The cancer-associated BST1 can be used in the generation of affinity reagents, including antibody, that bind specifically to BST1 and can be targeted by such affinity reagents as the basis of treatment.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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