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Anti-Bradykinin B2 receptor Therapeutic Antibody, Non-Fucosylated (BioBet-597ZP) (CAT#: BioBet-597ZP) Datasheet

Target
Bradykinin B2 receptor
Isotype
IgG
Description
Anti-Bradykinin B2 receptor Therapeutic Antibody, Non-Fucosylated (BioBet-597ZP) is a humanized monoclonal IgG antibody against Bradykinin B2 receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Bradykinin B2 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BDKRB2
Full Name
bradykinin receptor B2
Background
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
Alternative Names
BDKRB2; bradykinin receptor B2; B2R; BK2; BK-2; BKR2; BRB2; BKB2R; Bradykinin B2 receptor
Gene ID
624
UniProt ID
P30411
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with BDKRB2 include Hereditary Angioedema and Angioedema.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Field of research
Immune System antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn30, Asn39, and Asn207 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-597ZP
Host
Humanized
Species Reactivity
Human
Description
The anti-BKB2R antibody having the variable region sequences are useful for altering one or more of BKB2R of and/or GSK-3 signaling pathways for the treatment of diseases, disorders and conditions such as cancer, diabetes, cardiovascular disorders and other conditions.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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