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Anti-Bone morphogenetic protein receptor Antibody, Non-Fucosylated (BioBet-604ZP) (CAT#: BioBet-604ZP) Datasheet

Target
Bone morphogenetic protein receptor
Isotype
IgG
Description
Anti-Bone morphogenetic protein receptor Antibody, Non-Fucosylated (BioBet-604ZP) is a mouse monoclonal IgG antibody against Bone morphogenetic protein receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Bone morphogenetic protein receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BMPR
Full Name
Bone morphogenetic protein receptor
Background
There are three bone morphogenetic protein receptors in humans. Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. They belong to a class of receptor serine/threonine kinases that bind members of the TGF beta superfamily of ligands-the Bone morphogenetic proteins. Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signalling.
Alternative Names
BMPR; Bone morphogenetic protein receptor; BMPR2; BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK; ACVR1; BMPR1A; BMPR1B
UniProt ID
Q13873
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with BMPR2 include Pulmonary Hypertension, Primary, 1 and Pulmonary Venoocclusive Disease 1, Autosomal Dominant.
Related Pathways
Its related pathways are Signaling by GPCR and Signaling by BMP.
Function
On the ligand binding, a receptor complex composed of two type II and two type I transmembrane serine/threonine kinases is formed. Type II receptors phosphorylate and activate type I receptors, and type I receptors autophosphorylate, then bind and activate SMAD transcriptional regulators. Combined with BMP7, BMP2 and BMP4, the efficiency is low. The binding is weak, but the presence of type I receptors enhances BMPs. Adipogenesis is mediated by GDF6.
Field of research
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn55, Asn110, Asn126, and Asn827 2.Modification sites at PhosphoSitePlus 3.Glycosylation from GlyConnect
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-604ZP
Host
Mouse
Species Reactivity
Human
Description
The antibody binding bone morphogenetic protein receptor (BMPR) are useful to treat diseases such as cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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