Description
Anti-BMP9 Antibody, Non-Fucosylated (BioBet-916ZP) is a mouse monoclonal IgG antibody against BMP9. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Anemia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BMP9 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GDF2
Full Name
growth differentiation factor 15
Background
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia.
Alternative Names
GDF2; growth differentiation factor 2; BMP9; HHT5; BMP-9
Gene ID
2658
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with GDF2 include Telangiectasia, Hereditary Hemorrhagic, Type 5 and Hereditary Hemorrhagic Telangiectasia.
Related Pathways
Its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA.
Function
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
Post-translational modifications
1.A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn71 and Asn136
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-916ZP
Description
This is an anti-BMP9 (Bone morphogenetic protein-9) monoclonal antibody binding to human BMP9, used for the treatment of anemia such as renal anemia, cancer anemia or the like.
Antibody Indication
Anemia
