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Anti-BMP-6 Antibody, Non-Fucosylated (Antibody I) (CAT#: BioBet-602ZP) Datasheet

Target
BMP-6
Isotype
IgG4
Description
Anti-BMP-6 Antibody, Non-Fucosylated (BioBet-602ZP) is a human monoclonal IgG4 antibody against BMP-6. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Chronic Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BMP-6 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BMP-6
Full Name
bone morphogenetic protein 6
Background
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Alternative Names
BMP6; bone morphogenetic protein 6; VGR; VGR1; BMP-6
Gene ID
654
UniProt ID
P22004
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with BMP6 include Hemochromatosis, Type 5 and Renal Fibrosis.
Related Pathways
Its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA.
Function
Induces cartilage and bone formation.
Post-translational modifications
1.Glycosylation at Asn241, Asn269, Asn386, Ser398, Asn404, and Asn454 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4
Antibody Clone
Antibody I
Host
Human
Species Reactivity
Human
Description
The human monoclonal antibody, which specifically bind to BMP6 with high affinity, they are used for treating diseases associated with abnormal bone formation and ossification mediated by BMP6.
Antibody Indication
Chronic Disease

Chronic Disease

Related Products

Anti-BMP-6 Antibody, Non-Fucosylated (Antibody II) (CAT#: BioBet-603ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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