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Anti-Beta-secretase 1 Antibody, Non-Fucosylated (BioBet-592ZP) (CAT#: BioBet-592ZP) Datasheet

Target
Beta-secretase 1
Isotype
IgG
Description
Anti-Beta-secretase 1 Antibody, Non-Fucosylated (BioBet-592ZP) is a mouse monoclonal IgG antibody against Beta-secretase 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Alzheimer's Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Beta-secretase 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BACE1
Full Name
beta-site APP-cleaving enzyme 1
Background
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Alternative Names
BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC10
Gene ID
23621
UniProt ID
P56817
Cellular Localization
Golgi apparatus, Plasma membrane, Endosome, Lysosome, Endoplasmic reticulum
Involvement in Disease
Diseases associated with BACE1 include Alzheimer Disease and Tracheitis.
Related Pathways
Its related pathways are Neuroscience and Copper homeostasis.
Function
Responsible for the proteolysis of amyloid precursor protein (APP). The cleaved n-terminal a-β-amyloid peptide sequence, the remaining applications between 671 and 672, resulted in the generation and extracellular release of beta-cleaved soluble applications, and a corresponding cell-related c-terminal fragment after release The gamma secretase. Cut CHL1 (by similarity).
Field of research
Cell Biology and Cellular Response antibody; Neuroscience antibody
Post-translational modifications
N-Glycosylated. Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein. Palmitoylation mediates lipid raft localization.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-592ZP
Host
Mouse
Species Reactivity
Human
Description
This is a therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo.
Antibody Indication
Alzheimer's Disease

Alzheimer's Disease

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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