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Anti-BCMA Antibody, Non-Fucosylated (BioBet-1780ZP) (CAT#: BioBet-1780ZP) Datasheet

Target
BCMA
Isotype
IgG1
Description
Anti-BCMA Antibody, Non-Fucosylated (BioBet-1780ZP) is a humanized afucosylated monoclonal IgG1 antibody against BCMA. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Multiple myeloma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BCMA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF17
Full Name
tumor necrosis factor receptor superfamily member 17
Background
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.

TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).
Alternative Names
TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, tumor necrosis factor receptor superfamily member 17, TNF receptor superfamily member 17
Gene ID
Human: 608; Mouse: 21935
UniProt ID
Human: Q02223; Mouse: O88472
Function
The protein encoded by this gene is a member of the TNF receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to tumor necrosis factor (ligand) superfamily member 13b (TNFSF13B / TALL-1 / BAFF) and cause NF-κB and MAPK8 / JNK activation. The receptor also binds to various members of the TRAF family, so it may transduce signals for cell survival and proliferation. [7]
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-1780ZP
Host
Humanized afucosylated
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Multiple myeloma

Multiple myeloma

Related Products

Anti-BCMA Antibody, Half-Life Extended (AES-0622-ZP1021) (CAT#: AES-0622-ZP1021)
Anti-BCMA Antibody, On-Target (AES-0622-ZP693) (CAT#: AES-0622-ZP693)
Anti-BCMA Antibody, Non-Fucosylated (BioBet-1832ZP) (CAT#: BioBet-1832ZP)
Anti-BCMA Antibody, Recycling (AES-0622-ZP37) (CAT#: AES-0622-ZP37)
Anti-BCMA Antibody, ADCC Enchanced (BioBet-CB-056LX) (CAT#: BioBet-CB-056LX)
Anti-BCMA Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP365) (CAT#: AES-0622-ZP365)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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