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Anti-BAG family molecular chaperone regulator 3 Antibody, Non-Fucosylated (BioBet-593ZP) (CAT#: BioBet-593ZP) Datasheet

Target
BAG family molecular chaperone regulator 3
Isotype
IgG
Description
Anti-BAG family molecular chaperone regulator 3 Antibody, Non-Fucosylated (BioBet-593ZP) is a mouse monoclonal IgG antibody against BAG family molecular chaperone regulator 3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BAG family molecular chaperone regulator 3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BAG3
Full Name
BCL2-associated athanogene 3
Background
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Alternative Names
BAG3; BCL2-associated athanogene 3; BIS; MFM6; BAG-3; CAIR-1
Gene ID
9531
UniProt ID
O95817
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with BAG3 include Myopathy, Myofibrillar, 6 and Cardiomyopathy, Dilated, 1Hh.
Related Pathways
Its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME).
Function
HSP70 and HSC70 chaperones are para-chaperone proteins. As a nucleoside exchange factor (NEF), it promotes the release of ADP from HSP70 and HSC70 proteins, thereby triggering the release of client/substrate proteins. The release of nucleotides is mediated through the nucleotide binding domain (NBD) of HSPA8/HSC70, and the release of the substrate is mediated through the substrate binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Participate in HSF1 nuclear and plasma transport.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody
Post-translational modifications
1.Ubiquitination at Lys450 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-593ZP
Host
Mouse
Species Reactivity
Human
Description
The use of BAG3 antibody as a medicament, particular for use in the treatment of pancreatic tumours or other pathologies of immune, inflammatory, neoplastic and/or degenerative nature.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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