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Anti-BAFF Receptor Antibody, Non-Fucosylated (CAT#: BioBet-1380ZP) Datasheet

Target
BAFF Receptor
Isotype
IgG
Description
Anti-BAFF Receptor Antibody, Non-Fucosylated (BioBet-1380ZP) is a human monoclonal IgG antibody against BAFF Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Multiple Sclerosis; Relapsing-Remitting; Pemphigus vulgaris
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced BAFF Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF13C
Full Name
tumor necrosis factor receptor superfamily, member 13C
Background
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Alternative Names
TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
Gene ID
115650
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFRSF13C include Immunodeficiency, Common Variable, 4 and Common Variable Immunodeficiency.
Related Pathways
Its related pathways are NF-KappaB Family Pathway and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1380ZP
Host
Human
Species Reactivity
Human
Description
VAY736 is a human immunoglobulin of the G class (IgG1/k) monoclonal antibody (mAb) designed to specifically bind the BAFF receptor. VAY736 can be used for treatment of relapsing-remitting multiple sclerosis.
Antibody Indication
Multiple Sclerosis; Relapsing-Remitting; Pemphigus vulgaris

Multiple Sclerosis; Relapsing-Remitting; Pemphigus vulgaris

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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