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Anti-B7 Related protein Antibody, Non-Fucosylated (AMG 557) (CAT#: BioBet-591ZP) Datasheet

Target
B7 Related protein
Isotype
IgG
Description
Anti-B7 Related protein Antibody, Non-Fucosylated (BioBet-591ZP) is a human monoclonal IgG antibody against B7 Related protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Psoriasis; Systemic Lupus Erythematosus
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced B7 Related protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
B7RP
Full Name
B7 Related protein
Background
B7 is a type of peripheral membrane protein found on activated antigen presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal or a coinhibitory signal to enhance or decrease the activity of a MHC-TCR signal between the APC and the T cell, respectively. Besides being present on activated APCs, B7 is also found on T-cells themselves.
Alternative Names
B7RP; B7 Related protein; AMG 557, MEDI5872
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ICOSLG include Autoimmune Disease Of Exocrine System and Immune System Disease.
Related Pathways
Its related pathways are ICos-ICosL Pathway in T-Helper Cell and Innate Immune System.
Function
T cell specific cell surface receptor ICOS ligand. As a co-stimulatory signal for t cell proliferation and cytokine secretion; it can also induce b cell proliferation and differentiation into plasma cells. It plays an important role in mediating the response of local tissues to inflammatory conditions and modulating secondary immune responses by co-stimulating memory T cell function (through similarity).
Post-translational modifications
1.Glycosylation at Asn137, Asn173, Asn186, Asn70, Asn102, and Asn225 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AMG 557
Host
Human
Species Reactivity
Human
Description
AMG 557 is a fully human monoclonal antibody, used for the subcutaneous treatment of autoimmune disease like Systemic Lupus Erythematosus.
Antibody Indication
Psoriasis; Systemic Lupus Erythematosus

Psoriasis; Systemic Lupus Erythematosus

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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