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Anti-B-type natriuretic peptide Antibody, Non-Fucosylated (BioBet-1478ZP) (CAT#: BioBet-1478ZP) Datasheet

Target
B-type natriuretic peptide
Isotype
IgG
Description
Anti-B-type natriuretic peptide Antibody, Non-Fucosylated (BioBet-1478ZP) is a human monoclonal IgG antibody against B-type natriuretic peptide. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
BNP Test
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced B-type natriuretic peptide antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
NPPB
Full Name
notch 3
Background
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Alternative Names
NPPB; natriuretic peptide B; BNP; B-type natriuretic peptide
Gene ID
4879
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with NPPB include Constrictive Pericarditis and Systolic Heart Failure.
Related Pathways
Its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cardiomyocyte hypertrophy.
Function
Cardiac hormones may act as paracrine anti-fibrotic factors in the heart. It also plays a key role in the stability of cardiovascular homeostasis through natriuretic, diuretic, vascular relaxation, and inhibition of the secretion of renin and aldosterone. It specifically binds and stimulates cGMP production of NPR1 receptor. Binding to clear receptor NPR3.
Field of research
Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1478ZP
Host
Human
Species Reactivity
Human
Description
This is an antibody that binds to human NT- proBNP. Monoclonal antibody 15F11/NT-proBNP complexes can be magnetically captured and immobilized for BNP test which fulfils the basic requirements regarding analytical performance, storage stability of its cartridges.
Antibody Indication
BNP Test

BNP Test

Related Products

Anti-B-type natriuretic peptide Antibody, Non-Fucosylated (BioBet-1479ZP) (CAT#: BioBet-1479ZP)
Anti-B-type natriuretic peptide Antibody, Non-Fucosylated (201.3) (CAT#: BioBet-1481ZP)
Anti-B-type natriuretic peptide Antibody, Non-Fucosylated (8.1) (CAT#: BioBet-1480ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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