Book a Meeting

Anti-B-Raf Antibody, Non-Fucosylated (BioBet-605ZP) (CAT#: BioBet-605ZP) Datasheet

Target
B-Raf
Isotype
IgG
Description
Anti-B-Raf Antibody, Non-Fucosylated (BioBet-605ZP) is a humanized monoclonal IgG antibody against B-Raf. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced B-Raf antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
BRAF
Full Name
B-Raf proto-oncogene, serine/threonine kinase
Background
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
Alternative Names
BRAF; B-Raf proto-oncogene, serine/threonine kinase; NS7; BRAF1; RAFB1; B-RAF1; B-Raf
Gene ID
673
UniProt ID
P15056
Cellular Localization
Plasma membrane, Nucleus
Involvement in Disease
Diseases associated with BRAF include Cardiofaciocutaneous Syndrome 1 and Lung Cancer.
Related Pathways
Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Negative regulation of MAPK pathway.
Function
Protein kinase is involved in the transduction of mitotic signals from the cell membrane to the nucleus (possibly). Phosphorylate MAP2K1, thereby activating the mapkinase signal transduction pathway. May be involved in the postsynaptic response of hippocampal neurons.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Signaling Transduction antibody
Post-translational modifications
Phosphorylation at Ser-365 by SGK1 inhibits its activity. Methylation at Arg-671 decreases stability and kinase activity. Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-605ZP
Host
Humanized
Species Reactivity
Human
Description
The monoclonal antibody specifically recognizing B-Raf mutant proteins can be used to detect whether there are mutations in the B-Raf proteins of the tissues of an animal or a human in order to provide the basis for the diagnosis and treatment of skin cancer and other various cancers clinically.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.