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Anti-B-lymphocyte antigen CD20 Antibody, Non-Fucosylated (BLX-301) (CAT#: BioBet-1244ZP) Datasheet

Target
B-lymphocyte antigen CD20
Isotype
IgG
Description
Anti-B-lymphocyte antigen CD20 Antibody, Non-Fucosylated (BioBet-1244ZP) is a humanized monoclonal IgG antibody against B-lymphocyte antigen CD20. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Non-Hodgkin's Lymphoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced B-lymphocyte antigen CD20 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MS4A1
Full Name
membrane-spanning 4-domains, subfamily A, member 1
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Alternative Names
MS4A1; membrane-spanning 4-domains, subfamily A, member 1; B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-1
Gene ID
931
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with MS4A1 include Immunodeficiency, Common Variable, 5 and Common Variable Immunodeficiency.
Related Pathways
Its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
b lymphocyte-specific membrane protein, which is involved in the regulation of cellular calcium influx necessary for the development, differentiation and activation of b lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). After activation of b-cell receptor/BCR, it acts as a component of stored and operated calcium (SOC) channels to promote calcium influx (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Field of research
Cancer antibody; Developmental Biology antibody; Immune System antibody; B cell Marker antibody; Immature B Cell Marker antibody; Inflammatory Cell Marker antibody; Tumor-infiltrating Lymphocyte Study antibody
Post-translational modifications
Phosphorylated. Might be functionally regulated by protein kinase(s).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BLX-301
Host
Humanized
Species Reactivity
Human
Description
BLX-301 is a humanized and glyco-optimized anti-CD20 antibody for the treatment of non-Hodgkin's B-cell lymphoma and other B-cell malignancies.
Antibody Indication
Non-Hodgkin's Lymphoma

Non-Hodgkin's Lymphoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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