Description
Anti-AQP4 Antibody, Non-Fucosylated (BioBet-580ZP) is a human monoclonal IgG1 antibody against AQP4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Neuromyelitis optica
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced AQP4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
AQP4
Full Name
aquaporin 4
Background
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alternative Names
AQP4; aquaporin 4; MIWC; HMIWC
Gene ID
361
UniProt ID
P55087
Cellular Localization
Plasma membrane, Endosome
Involvement in Disease
Diseases associated with AQP4 include Brain Edema and Neuromyelitis Optica.
Related Pathways
Its related pathways are Aquaporin-mediated transport and Nanog in Mammalian ESC Pluripotency.
Function
Form a specific water channel. It plays an important role in brain water homeostasis and colloidal solute transport. Normal water exchange is required at the blood-brain interface. Cerebrospinal fluid flows along the paravascular space around the perforating artery into the cerebral cortex and brain parenchyma at a normal level, and is necessary for the normal drainage of interstitial fluid along the side drainage channels. Therefore, it is required for the normal removal of solutes in the interstitial fluid of the brain, including APP-derived soluble-amyloid peptides. It plays a redundant role (similarity) in urine homeostasis and urine concentration.
Post-translational modifications
Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40% (By similarity).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-580ZP
Description
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO, a study on antibody titre. Neuromyelitis optica (NMO) is an autoimmune inflammatory disorder of the central nervous system. In most NMO patients, autoantibody to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes.
Antibody Indication
Neuromyelitis optica
