Anti-APCS Antibody, Highly Galactosylated (BioBet-GA-071ZP) (CAT#: BioBet-GA-071ZP) Datasheet

APCS

Amyloid P Component, Serum

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]

Amyloid P component, serum; "9.5S alpha-1-glycoprotein"; MGC88159; "pentraxin-2"; "pentraxin-related"; PTX2; SAP

Extracellular region or secreted

Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Regulation of Wnt-mediated beta catenin signaling and target gene transcription.

Tumor suppressor gene. It promotes the rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is related to its phosphorylation status. Activate the GEF activity of SPATA13 and ARHGEF4. It plays a role in cell migration induced by hepatocyte growth factor (HGF). MMP9 is required to be upregulated in colorectal tumor cells through the JNK signaling pathway. As a stabilizing mediator of erbb2-dependent microtubules in the cell cortex. This is necessary for the localization of MACF1 on the cell membrane, and the localization of MACF1 is critical to its function in microtubule stability.

Cell Biology and Cellular Response antibody; Neuroscience antibody

N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-GA-071ZP

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to APCS. Dezamizumab is a human monoclonal antibody that can be potentially used in the treatment of AL amyloidosis.

AL amyloidosis

AL amyloidosis