Description
Anti-APCS Antibody, Highly Galactosylated (BioBet-GA-071ZP) is a human IgG1, κ antibody against APCS which contains with a high level of galactosylation.
Antibody Indication
AL amyloidosis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced APCS antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
APCS
Full Name
Amyloid P Component, Serum
Background
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
Alternative Names
Amyloid P component, serum; "9.5S alpha-1-glycoprotein"; MGC88159; "pentraxin-2"; "pentraxin-related"; PTX2; SAP
Gene ID
325
UniProt ID
P02743
Cellular Localization
Extracellular region or secreted
Genecards
583
Involvement in Disease
Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Regulation of Wnt-mediated beta catenin signaling and target gene transcription.
Related Pathways
Tumor suppressor gene. It promotes the rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is related to its phosphorylation status. Activate the GEF activity of SPATA13 and ARHGEF4. It plays a role in cell migration induced by hepatocyte growth factor (HGF). MMP9 is required to be upregulated in colorectal tumor cells through the JNK signaling pathway. As a stabilizing mediator of erbb2-dependent microtubules in the cell cortex. This is necessary for the localization of MACF1 on the cell membrane, and the localization of MACF1 is critical to its function in microtubule stability.
Function
Cell Biology and Cellular Response antibody; Neuroscience antibody
Field of research
N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-071ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to APCS. Dezamizumab is a human monoclonal antibody that can be potentially used in the treatment of AL amyloidosis.
Antibody Indication
AL amyloidosis
