Anti-AOC3 Antibody, Non-Fucosylated (BioBet-070ZP) (CAT#: BioBet-070ZP) Datasheet

AOC3

Amine Oxidase, Copper Containing 3

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Vepalimomab; 195158-85-1; AOC3; amine oxidase, copper containing 3 (vascular adhesion protein 1); membrane primary amine oxidase; HPAO; VAP 1; VAP1; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase; SSAO; VAP-1;

Plasma membrane

Diseases associated with AOC3 include Diabetic Angiopathy and Diabetes Mellitus.

Its related pathways are Tyrosine metabolism and beta-Alanine metabolism (KEGG).

Cell adhesion proteins are involved in lymphocyte extravasation and recirculation by mediating lymphocytes to bind to peripheral blood lymph node vascular endothelial cells in an L-selectin-independent manner. Has semicarbazide sensitive (SSAO) monoamine oxidase activity. May play a role in fat formation

Neuroscience antibody; Signaling Transduction antibody

Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. N- and O-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4, κ

Timolumab

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to AOC3. Timolumab is a human monoclonal antibody that can be potentially used in the treatment of Psoriasis, Rheumatoid arthritis, Primary sclerosing cholangitis.

Unknown

Unknown