Description
Anti-Angiotensin-II Type-I Receptor Antibody, Non-Fucosylated (BioBet-547ZP) is a humanized monoclonal IgG antibody against Angiotensin-II type-I receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Angiotensin-II type-I receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
AGTR1
Full Name
angiotensin II receptor, type 1
Background
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
Alternative Names
AGTR1; angiotensin II receptor, type 1; AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B; Angiotensin-II type-I receptor
Gene ID
185
UniProt ID
P30556
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with AGTR1 include Renal Tubular Dysgenesis and Hypertension, Essential.
Related Pathways
Its related pathways are Clathrin-mediated endocytosis and RET signaling.
Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody
Post-translational modifications
C-terminal Ser or Thr residues may be phosphorylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
6313/G2
Description
The use of monoclonal antibody to the angiotensin-II type-I receptor is for the treatment of cancer and vascular smooth muscle cell proliferation.
Antibody Indication
Cancer
