Product Type
Fc Silent Antibody
Description
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies. However, engaging immune effectors through FcγR and complement interactions may be detrimental to certain mAb mechanisms of action and so Fc-null or -silenced antibodies may be desired.
Creative Biolabs uses site-directed mutagenesis technology to generate Fc-silenced antibody with reduced effector functions. The mutated Fc domains eliminate the binding of Fc receptors (FcγR, FcR), thereby leading to a significant reduction in ADCC and CDC in comparison to WT IgG.
Immunogen
Single chain variable fragment (scFv)-displaying phages from the IONTAS phage library λ with a phage diversity of 1.6・10^10 were used to select scFvs, which bind biotinylated α-latrotoxin from the ...
Species
Insect
Cross reactivity
Latrodectus tredecimguttatus (Mediterranean blaChicken widow spider)
Clonality
Monoclonal
Clone Number
TPL0020_02_G9
Conjugation
Unconjugated
Source
This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Buffer
PBS only
Application
EL
Storage Instructions
Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommend this antibody be handled under sterile conditions. For lon...
Official Name
ANG
Alternative Names
ANG, ALS9, HEL168, RAA1, RNASE4, RNASE5, angiogenin, ribonuclease, RNase A family, 5, angiogenin
