Anti-Anaplastic Lymphoma Kinase Antibody, Non-Fucosylated (4G10) (CAT#: BioBet-551ZP) Datasheet

ALK

anaplastic lymphoma receptor tyrosine kinase

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

ALK; anaplastic lymphoma receptor tyrosine kinase

Plasma membrane

Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma.

Its related pathways are Activation of cAMP-Dependent PKA and Actin Nucleation by ARP-WASP Complex.

Neuronal receptor tyrosine kinases are essentially and transiently expressed in specific areas of the central and peripheral nervous systems, and play an important role in the development and differentiation of the nervous system. By specifically activating the mitogen-activated protein kinase (MAPK) pathway, signals are transmitted from the ligand on the cell surface. Almost only the first tyrosine of the Y-x-x-x-Y-Y motif is phosphorylated. With the activation of the ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as MAPK1/ERK2 and MAPK3/ERK1. As a receptor for secreting growth factor ligand polyiodine factor (PTN) and a PTN-related factor midkine (MDK), it participates in PTN and MDK signal transduction. PTN binding can induce the activation of MAPK pathway, which is of great significance for PTN anti-apoptotic signal and regulation of cell proliferation. mdk binding induces the phosphorylation of ALK's target insulin receptor substrate (IRS1), activating mitogen-activated protein kinases (MAPKs) and pi3-kinase, leading to induction of cell proliferation. It is possible to activate nf-kpa-b through IRS1 and AKT serine/threonine kinase. Recruiting IRS1 to activate ALK and activation of nf-kpa-b are critical to the autocrine growth and survival signals of MDK.

Cancer antibody; Controls and Markers antibody; Neuroscience antibody

Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association. N-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

4G10

Mouse

Human

This antibody is suitable for the local treatment of tumors, for example, metastatic cancer or tumors, in particular, glioblastoma.

Glioblastoma

Glioblastoma