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Anti-Amphiregulin Therapeutic Antibody, Non-Fucosylated (BioBet-581ZP) (CAT#: BioBet-581ZP) Datasheet

Target
Amphiregulin
Isotype
IgG
Description
Anti-Amphiregulin Therapeutic Antibody, Non-Fucosylated (BioBet-581ZP) is a humanized monoclonal IgG antibody against Amphiregulin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Psoriasis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Amphiregulin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
AREG
Full Name
amphiregulin
Background
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.
Alternative Names
AREG; amphiregulin; AR; SDGF; AREGB; CRDG
Gene ID
374
UniProt ID
P15514
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with AREG include Ovarian Cystadenoma and Colorectal Cancer.
Related Pathways
Its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA.
Function
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Post-translational modifications
1.Glycosylation at Asn30, Ser41, Thr52, Ser53, Asn113, Asn119, and Thr169 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-581ZP
Host
Humanized
Species Reactivity
Human
Description
Anti-AR antibody are humanized monoclonal antibody used for inhibiting cancer cell growth, treating cancer or psoriasis.
Antibody Indication
Cancer; Psoriasis

Cancer; Psoriasis

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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