Anti-Alpha Enolase Antibody, Non-Fucosylated (BioBet-818ZP) (CAT#: BioBet-818ZP) Datasheet

ENO1

enolase 1, (alpha)

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

ENO1; enolase 1, (alpha)

Plasma membrane

Diseases associated with ENO1 include Hashimoto Encephalopathy and Cancer-Associated Retinopathy.

Its related pathways are Glucose metabolism and Validated targets of C-MYC transcriptional activation.

2-phosphoglycerate is converted to phosphoenolpyruvate. In addition to glycolysis, it also participates in processes such as growth control, hypoxia tolerance, and allergic reactions. It may also play a role in the intravascular and extracellular fibrinolytic system because it can act as a receptor and activator of plasminogen on the surface of several cell types (such as white blood cells and neurons). Stimulate the production of immunoglobulin.

Cancer antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody

ISGylated.

Protein Based Therapies
Monoclonal antibody (mAb)

Chicken IgY

BioBet-818ZP

Chicken

Human

The antibody against α-enolase I can be used in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.

Autoimmune Diseases; Cancer

Autoimmune Diseases; Cancer