Description
Anti-ALCAM Antibody, Non-Fucosylated (BioBet-549ZP) is a human monoclonal IgG1 antibody against ALCAM. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ALCAM antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ALCAM
Full Name
activated leukocyte cell adhesion molecule
Background
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Alternative Names
ALCAM; activated leukocyte cell adhesion molecule; MEMD; CD16; AT002, CBAS-173, EJ212/007-Cl2-5
Gene ID
214
UniProt ID
Q13740
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with ALCAM include Stork Bite and Melanoma.
Related Pathways
Its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and L1CAM interactions.
Function
Cell adhesion molecules regulate the contact between heterotypic and homotypic cells by interacting with CD6. Promotes the activation and proliferation of t cells by interacting with CD6. Through the interaction with CD6, it promotes the formation and maturation of immune synapses. Mediates homotypic interaction with cells expressing ALCAM. Normal hematopoietic stem cells need to be transplanted into bone marrow. The attachment of dendritic cells to endothelial cells is mediated by homotypic interactions. It inhibits endothelial cell migration and promotes endothelial tube formation through homotypic interaction. The normal organization of the lymphatic network is required. This is necessary for the transplantation of normal hematopoietic stem cells into the bone marrow. Play a role in the hematopoietic process; normal number of hematopoietic stem cells in the bone marrow. Promote the proliferation and differentiation of osteoblasts in vitro (through similarity). Promote neurite extension, axon growth and axon guidance; axons preferentially grow on the surface containing ALCAM. Mediates the growth and pathfinding (through similarity) of retinal ganglion cell axons. 发送反馈 历史记录
Post-translational modifications
Glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
AT002
Description
AT002 is a human IgG1 antibody that targets a cell surface protein known as Activated Leukocyte Cell Adhesion Molecule (ALCAM or CD166). The potential therapeutic use of an anti-ALCAM antibody includes the treatment of cancer, autoimmune and inflammatory diseases.
Antibody Indication
Inflammatory Diseases
