Anti-ADAMTS-5 Antibody, Non-Fucosylated (CAT#: BioBet-524ZP) Datasheet

ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

Extracellular region or secreted

Diseases associated with ADAMTS5 include Osteoarthritis and Arthritis.

Its related pathways are Degradation of the extracellular matrix and Metabolism of proteins.

Metalloproteinases play an important role in connective tissue organization, development, inflammation, arthritis and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme with hyaluronan-based proteolytic activity on chondroitin sulfate proteoglycans (CSPGs), including aggrecan, versican, brevican and neurocan. The cleavage in the transparent membrane occurs on the gal-xaa recognition motif. It plays a role in embryonic development, including morphogenesis of limbs and heart, and skeletal muscle development through its versican remodeling properties. Participate in the development of brown adipose tissue and the browning of white adipose tissue. T lymphocytes play an important role in migration from draining lymph nodes after virus infection.

The precursor is cleaved by a furin endopeptidase. C- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation can mediate the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4

BioBet-524ZP

Human

Human

The anti-ADAMTS-5 antibody are useful in the treatment of a condition associated with cartilage degradation. In particular, such degradation is observed in osteoarthritis and in other forms of arthritides.

Osteoarthritis

Osteoarthritis