Anti-ADAM15 Antibody, Non-Fucosylated (CAT#: BioBet-516ZP) Datasheet

ADAM15

ADAM metallopeptidase domain 15

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

ADAM15; ADAM metallopeptidase domain 15; MDC15; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloprotease RGD disintegrin protein; a disintegrin and metalloproteinase domain 15 (metargidin); metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

Endomembrane system

Diseases associated with ADAM15 include Lung Cancer.

Its related pathways are Degradation of the extracellular matrix and Notch Signaling Pathway (sino).

Active metalloprotease has gelatin decomposition and collagen decomposition activities. Play a role in wound healing. Mediates heterotypic intraepithelial cell/T cell interaction and homotypic T cell aggregation. Inhibit β-1 integrin-mediated cell adhesion and airway smooth muscle cell migration. By driving the expression of α-v/β-1 integrin (ITAGV-ITGB1) on the cell surface through ERK1/2 inactivation, it inhibits the movement of cells on or to fibronectin. E-cadherin is responsive to growth factor deprivation. It plays a role in the migration of glomerular cells. Play a role in pathological new blood vessel formation. May play a role in cartilage remodeling. The sperm epididymis may undergo proteolysis during the maturation and acrosome reaction. Through its integrin domain, it may play a role in sperm-egg binding.

Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

1.The precursor is cleaved by a furin endopeptidase. 2.Modification sites at PhosphoSitePlus 3.Phosphorylation increases association with PTKs.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-516ZP

Human

Human

ADCC-Enhanced anti-ADAM15 (8F7) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.

Cancer

Cancer