Description
Anti-ACVRL1 Antibody, Non-Fucosylated (BioBet-061ZP) is a human monoclonal IgG2, κ antibody against ACVRL1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ACVRL1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
Activin A Receptor Like Type 1
Background
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Alternative Names
Activin A receptor type II-like 1; activin receptorlike kinase 1; ALK1; ALK-1; serine/threonine-protein kinase receptor R3; SKR3; transforming growth factor-beta superfamily receptor type I; TGF-B superfamily receptor type I; TSR-I; HHT2; ORW2
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ACVRL1 include Telangiectasia, Hereditary Hemorrhagic, Type 2 and Pulmonary Hypertension, Primary, 1.
Related Pathways
Its related pathways are Akt Signaling and PEDF Induced Signaling.
Function
Type I receptors of TGF-beta family ligands BMP9/GDF2 and BMP10 are important regulators of normal vascular development. On the ligand binding, a receptor complex composed of two type II and two type I transmembrane serine/threonine kinases is formed. Type II receptors phosphorylate and activate type I receptors, and type I receptors autophosphorylate, then bind and activate SMAD transcriptional regulators. You can also bind activin.
Field of research
Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
1. Glycosylation at Asn98 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-061ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to ACVRL1. Ascrinvacumab is a human monoclonal antibody that can be potentially used in the treatment of Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC).
Antibody Indication
Mesothelioma, pleural malignant, Hepatocellular carcinoma (HCC)
