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Anti-Activin A Antibody, Non-Fucosylated (BioBet-510ZP) (CAT#: BioBet-510ZP) Datasheet

Target
Activin A
Isotype
IgG
Description
Anti-Activin A Antibody, Non-Fucosylated (BioBet-510ZP) is a human monoclonal IgG antibody against Activin A. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Bone-related Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Activin A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Activin A
Full Name
activin A receptor
Background
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Alternative Names
ACVR; activin A receptor; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK; activin βA-subunit
Gene ID
3624
UniProt ID
Q04771
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ACVR1 include Fibrodysplasia Ossificans Progressiva and Brain Stem Glioma.
Related Pathways
Its related pathways are ALK2 signaling events and Akt Signaling.
Function
After the ligand binds, a receptor complex composed of two type II and two type I transmembrane serine/threonine kinases is formed. Type II receptors phosphorylate and activate type I receptors, which automatically phosphorylate and then bind and activate SMAD transcriptional regulators. Activin receptor. May involve the formation of left and right patterns during embryogenesis (through similarity).
Field of research
Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn102 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-510ZP
Host
Human
Species Reactivity
Human
Description
ADCC-Enhanced anti-Activin A (ActRIIa-hFc) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Bone-related Diseases

Bone-related Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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