Description
Anti-ACE Antibody, Non-Fucosylated (BioBet-497ZP) is a Rat monoclonal IgG antibody against ACE. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Lung Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ACE antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ACE
Full Name
angiotensin I converting enzyme
Background
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
Alternative Names
ACE; angiotensin I converting enzyme; DCP; ICH; ACE1; DCP1; CD143; MVCD
Gene ID
1636
UniProt ID
P12821
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with ACE include Microvascular Complications Of Diabetes 3 and Renal Tubular Dysgenesis.
Related Pathways
Its related pathways are Transcription_CREM signaling in testis and Peptide hormone metabolism.
Function
Angiotensin I is converted to angiotensin II by the release of terminal His-Leu, which leads to an increase in the vasoconstrictive activity of angiotensin. It also inactivates bradykinin, a powerful vasodilator. It also has glycosidase activity and can release GPI-anchored protein from the membrane by cleaving the mannose bond of the GPI part.
Field of research
Cell Biology and Cellular Response antibody
Post-translational modifications
Phosphorylated by CK2 on Ser-1299; which allows membrane retention.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
9B9
Description
The antibody demonstrated highly efficient and selective lung accumulation and thus has the potential for targeting drugs/genes to the pulmonary vasculature in different mouse models of human lung diseases, including numerous knockout models.
Antibody Indication
Lung Cancer
