Description
Anti-ABCB5 Antibody, Non-Fucosylated (BioBet-496ZP) is a human monoclonal IgG antibody against ABCB5. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ABCB5 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ABCB5
Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 5
Background
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al. , 2005 ).
Alternative Names
ABCB5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ABCB5beta; EST422562; ABCB5alph
Gene ID
340273
UniProt ID
Q2M3G0
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ABCB5 include Borna Disease and Melanoma.
Related Pathways
Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
Function
Drug efflux transporters exist in many stem cells and act as regulators of cell differentiation. It can mediate the extracellular outflow of rhodamine dye and the therapeutic drug doxorubicin. It is especially present in limbal stem cells and plays a key role in corneal development and repair.
Field of research
Cancer antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn17, Asn85, Asn91, Asn789, Asn371, Asn819, Asn390, Asn423, Asn910, Asn1104, and Asn1188 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-496ZP
Description
This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Anti-ABCB5 Antibody is a ATP-Binding Cassette protein. This antibody product is intended to be used to confirm cellular localization and expression level of ABCB5. ABCB5 antibody is ideal for Cancer and Signal Transduction research.
Antibody Indication
Cancer
