Description
This is a non-fucosylated ADCC-enhanced anti-Human ABCA1 biobetter antibdoy with clone 4/18.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ABCA1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ABCA1
Full Name
ATP-binding cassette, sub-family A (ABC1), member 1
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Alternative Names
ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; TGD; ABC1; CERP; ABC-1; HDLDT
Gene ID
19
UniProt ID
O95477
Cellular Localization
Plasma membrane, Endosome
Involvement in Disease
Diseases associated with ABCA1 include Tangier Disease and Hypoalphalipoproteinemia, Primary, 1.
Related Pathways
Its related pathways are Lipoprotein metabolism and Folate Metabolism.
Function
It catalyzes the transfer of specific phospholipids from the cytoplasm to the extramembrane/luminal lobes combined with ATP hydrolysis. Therefore, it participates in the transfer of phospholipids to apolipoproteins to form new high-density lipoproteins/HDLs. Preference is given to using phosphatidylcholine instead of phosphatidylserine. It may play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of new high-density lipoproteins/HDLs.
Post-translational modifications
Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
Clone 4/18
Description
This is a non-fucosylated ADCC-enhanced anti-Human ABCA1 biobetter antibdoy with clone 4/18.
Antibody Indication
Cancer
