Description
Anti-5AC Antibody, Non-Fucosylated (BioBet-388ZP) is a mouse monoclonal IgG1 antibody against 5AC. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Colorectal cancers
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced 5AC antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MUC5AC
Full Name
Mucin 5AC, Oligomeric Mucus/Gel-Forming
Background
MUC5AC (Mucin 5AC, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene.
Diseases associated with MUC5AC include Pseudomyxoma Peritonei and Pancreatic Cancer.
Among its related pathways are Metabolism of proteins and CLEC7A (Dectin-1) signaling.
Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent.
An important paralog of this gene is KCP.
Alternative Names
Ensituximab;1092658-06-4;NPC-1C;NEO-101;MUC5AC;mucin 5AC, oligomeric mucus/gel-forming;mucin 5, subtypes A and C, tracheobronchial/gastric;mucin-5AC;MUC5;gastric mucin;tracheobronchial mucin;major airway glycoprotein;lewis B blood group antigen;mucin-5 su
Gene ID
4586
UniProt ID
P98088
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with MUC5AC include Barrett Esophagus and Biliary Papillomatosis.
Related Pathways
Its related pathways are Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) and Metabolism of proteins.
Function
The glycoproteins that form a gel in the epithelium of the stomach and respiratory tract protect the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles. These microorganisms and particles are then removed by the hair ciliary system. Interacts with Helicobacter pylori in gastric epithelium, Barrett's esophagus and duodenal metaplasia.
Post-translational modifications
C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-388ZP
Description
This is a non-fucosylated ADCC-enhanced anti-5AC therapeutic biobetter antibody.
Antibody Indication
Colorectal cancers
