Non-fucosylated Anti-Human CD20 Therapeutic Antibody, an ADCC-Enhanced Biobetter [Lot: CB20-PZ48] (CAT#: BioBet-048ZP) Datasheet

Target
CD20
Isotype
Whole Human Antibody
Description
ADCC-enhanced Ocrelizumab is a non-fucosylated anti-CD20 therapeutic biobetter antibody. Creative Biolabs' Afuco™ technology platform allows for the control of glycosylation level, thereby achieving ADCC-Enhanced Anti-CD20 Ocrelizumab, a biobetter by reducing fucosylation of the Fc region of Ocrelizumab, leading to an increased binding affinity for the FcyR receptor on immune effector cells.
More specifically, the afucosylated therapeutic biobetter antibody was generated by recombinant DNA technology. It has been produced in CHO cells that are deficient for fucosylation and purified by affinity chromatography with protein G. The absence of the fucose residue from the N-glycans of IgG-Fc results in dramatic enhancement of antibody-dependent cellular cytotoxicity (ADCC).
Indication
Multiple sclerosis
Classification
Therapeutic antibody; biobetter
Patent
Not Available
Status
FDA-approved

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced rituximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MS4A1
Full Name
membrane spanning 4-domains A1
Background
This gene encodes a member of the membranespanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a Blymphocyte surface molecule which plays a role in the development and differentiation of Bcells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Alternative Names
B1, S7, Bp35, CD20, CVID5, MS4A2, LEU-16,
Gene ID
Cellular Localization
Plasma membrane
HGNC
OMIM
Involvement in Disease
Diseases associated with MS4A1 include Immunodeficiency, Common Variable, 5 and Common Variable Immunodeficiency.
Related Pathways
Its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers.
Function
b lymphocyte-specific membrane protein, which is involved in the regulation of cellular calcium influx necessary for the development, differentiation and activation of b lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). After activation of b-cell receptor/BCR, it acts as a component of stored and operated calcium (SOC) channels to promote calcium influx (PubMed:7684739, PubMed:12920111, PubMed:18474602).
Field of research
Cancer antibody; Developmental Biology antibody; Immune System antibody; B cell Marker antibody; Immature B Cell Marker antibody; Inflammatory Cell Marker antibody; Tumor-infiltrating Lymphocyte Study antibody
Post-translational modifications
Phosphorylated. Might be functionally regulated by protein kinase(s).
Trade name
Ocrevus
Groups
Approved, Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Accession Number
DB11988
CAS number
637334-45-3
Antibody Isotype
Humanized IgG1
Antibody Clone
Ocrelizumab
Description
Ocrelizumab, trade name Ocrvus, is a humanized anti-CD20 monoclonal antibody. It targets the CD20 marker on B lymphocytes and is therefore an immunosuppressive drug. It was developed by Genentech / Roche and was approved by the FDA in March 2017 for the treatment of multiple sclerosis.
Indication
Multiple Sclerosis, Primary Progressive
Relapsing Multiple Sclerosis (RMS)
UNII
A10SJL62JY

Ocrelizumab is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B lymphocytes that express the CD20 antigen. B lymphocytes are known to promote the pathogenesis of MS by activating pro-inflammatory T cells and secreting pro-inflammatory cytokines. Ocrelizumab promotes cytotoxicity of antibody-dependent cells and complement-mediated cell lysis by binding to CD20-expressing B lymphocytes. Ocrelizumab may induce antibody-dependent cytotoxicity, involving macrophages, natural killer cells, and cytotoxic T cells that work together to cause cell death.

Multiple Sclerosis, Primary Progressive
Relapsing Multiple Sclerosis (RMS)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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