Non-fucosylated Anti-Human CD11a (Odulimomab) Therapeutic Antibody (CAT#: BioBet-330ZP) Datasheet

ITGAL

Integrin Subunit Alpha L

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Efalizumab;raptiva;214745-43-4;hu1124;DB00095ITGAL;integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1;alpha polypeptide);CD11A;integrin alpha-L;LFA 1;LFA-1A;LFA-1 alpha;integrin gene promoter;CD11 antigen-like family member

Plasma membrane

Diseases associated with ITGAL include Immune-Complex Glomerulonephritis and Chronic Venous Insufficiency.

Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.

Integrin ITGAL/ITGB2 is the receptor for ICAM1, ICAM2, ICAM3 and ICAM4. The integrin ITGAL/ITGB2 is the receptor for F11R. Integin ITGAL/ITGB2 is the receptor for the secreted ubiquitin-like protein ISG15; this interaction is mediated by ITGAL. Participate in a variety of immune phenomena, including leukocyte-endothelial cell interaction, cytotoxic T cell-mediated killing, and antibody-dependent killing of granulocytes and monocytes. Contributes to natural killer cell toxicity. Participate in the adhesion and transport of leukocytes including T cells and neutrophils. There is a need to generate common lymphoid progenitor cells in the bone marrow, demonstrating its role in lymphogenesis (through similarity). Integrin ITGAL/ITGB2 is related to ICAM3 and can promote the phagocytosis of macrophages and neutrophils.

In resting T-cells, up to 41% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

Odulimomab

Mouse

Human

Recombinant monoclonal antibody to CD11a. Odulimomab is an investigational drug for the prevention of transplant rejection and for the treatment of various immunological diseases. It is a mouse monoclonal antibody directed against the alpha chain of the protein lymphocyte function-associated antigen 1 which is involved in immune reactions.

Psoriasis (infection in chronic moderate to severe plaque)

Psoriasis (infection in chronic moderate to severe plaque)