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Non-fucosylated Anti-Human PVRL4 (Enfortumab) Therapeutic Antibody (CAT#: BioBet-418ZP) Datasheet

Target
PVRL4
Isotype
IgG1, κ
Description
ADCC-enhanced Enfortumab is a non-fucosylated anti-PVRL4 therapeutic biobetter antibody.
Indication
Solid tumors
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced PVRL4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PVRL4
Alternative Names
PVRL4; poliovirus receptor-related 4; poliovirus receptor-related protein 4; LNIR; nectin 4; PRR4; Ig superfamily receptor LNIR; Nectin 4; Nectin-4; poliovirus receptor-related 4
UniProt ID
Q96NY8
Cellular Localization
Extracellular region or secreted, Plasma membrane
Involvement in Disease
Diseases associated with NECTIN4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Ectodermal Dysplasia.
Related Pathways
Its related pathways are Cell junction organization and Adhesion.
Function
It appears to be involved in cell adhesion through trans-homotype and -heterotype interactions, the latter including specific interactions with NECTIN1. It cannot be used as a receptor for herpes viruses to enter cells.
Post-translational modifications
The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
Enfortumab
Host
Human
Species Reactivity
Human
Description
ADCC-enhanced Enfortumab is a non-fucosylated anti-PVRL4 therapeutic biobetter antibody.
Indication
Solid tumors

Solid tumors

Related Products

Highly Galactosylated Anti-PVRL4 (Enfortumab) Antibody (CAT#: BioBet-GA-418ZP)
Highly Galactosylated Anti-PVRL4 (enfortumab vedotin) Antibody (CAT#: BioBet-GA-419ZP)
BetterBet™ Anti-PVRL4 On-Target Antibody (CAT#: AES-0622-ZP764)
BetterBet™ Anti-PVRL4 Recycling Antibody (CAT#: AES-0622-ZP108)
BetterBet™ Anti-PVRL4 FcγRIIB Binding Enhanced Antibody (CAT#: AES-0622-ZP436)
Non-fucosylated Anti-Human PVRL4 (enfortumab vedotin) Therapeutic Antibody (CAT#: BioBet-419ZP)
BetterBet™ Anti-PVRL4 Half-Life Extended Antibody (CAT#: AES-0622-ZP1092)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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