Non-fucosylated Anti-Human ERBB3 (Elgemtumab) Therapeutic Antibody (CAT#: BioBet-225ZP) Datasheet

ERBB3

Erb-B2 Receptor Tyrosine Kinase 3

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Patritumab; 1262787-83-6; AMG 888; U3-1287; ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3;

Plasma membrane, Extracellular region or secreted

Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial.

Its related pathways are RET signaling and Signaling by GPCR.

Tyrosine-protein kinase plays an important role as a cell surface receptor for neurotonin. Binds and is activated by neuregulin-1 (NRG1); ligand binding increases phosphorylation on tyrosine residues and promotes its association with phosphatidylinositol 3-kinase p85 subunit. It may also be activated by CSPG5. Participate in the regulation of myeloid cell differentiation.

Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody

Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

Elgemtumab

Human

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to ERBB3. Elgemtumab is a human monoclonal antibody that can be potentially used in the treatment of Cancers, head and neck. It binds to and locks HER3 in the inactive conformation and does not interfere with its interaction with neuregulin (NRG). The inactivated form of HER3 blocks the PI3K/Akt signaling pathway, thereby inhibiting cellular proliferation in HER2 or NRG expressing tumor cells.

Solid tumors

Solid tumors