Alternative Names
VASH2; vasohibin 2; vasohibin-2; vasohibin-like protein
Cellular Localization
Extracellular region or secreted, Cytoskeleton
Involvement in Disease
Diseases associated with VASH2 include Aarskog-Scott Syndrome.
Function
Tyrosine carboxypeptidase removes the c-terminal tyrosine residue of tubulin, thereby regulating microtubule dynamics and function. Spindle function and accurate chromosome segregation during mitosis are critical, because microcellular denucleation regulates the length and position of the mitotic spindle. As an activator of angiogenesis: expressed in the mononuclear cells of the bud front line, promote angiogenesis. Play a role in axon formation.
Field of research
Cell Biology and Cellular Response antibody; Developmental Biology antibody
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The anti-vasohibin 2 antibody is capable of recognizing vasohibin 2 protein at a high specificity and inhibiting the neovascularization promoting function of vasohibin 2 protein. Thus, a medicinal composition containing the anti-vasohibin 2 antibody is appropriately usable in, for example, treating diseases, such as cancer, where neovascularization should be inhibited.
