Non-Fucosylated Anti-Human Somatostatin receptor (BioBet-1312ZP) Therapeutic Antibody (CAT#: BioBet-1312ZP) Datasheet

SSTR

Somatostatin receptor

There are five known somatostatin receptors:SST1 (SSTR1), SST2 (SSTR2), SST3 (SSTR3), SST4 (SSTR4), SST5 (SSTR5). All are G protein-coupled seven transmembrane receptors.

Somatostatin receptor; SSTR; SSTR1; SSTR2; SSTR3; SSTR4; SSTR5

Plasma membrane

Diseases associated with SSTR2 include Type C Thymoma and Neuroendocrine Tumor.

Its related pathways are Signaling by GPCR and GPCRs, Other.

Somatostatin 14 and -28 receptors. This receptor is coupled through the inhibitory effect of pertussis toxin-sensitive G protein on adenosine cyclase. In addition, it stimulates phosphotyrosine phosphatase and PLC through pertussis toxin-insensitive and sensitive G protein. By inhibiting voltage-dependent calcium channels to inhibit calcium entry. As a functionally dominant somatostatin receptor, it mediates the inhibitory effect of somatostatin-14 on hormone secretion in pancreatic-and-cells. It inhibits cell growth by enhancing phosphorylation of MAPK1 and MAPK2 and subsequent upregulation of CDKN1B. Stimulate neuron migration and axon growth, which may be involved in neuron development and maturation during brain development. PTPN6 mediates the negative regulation of insulin receptor signaling. Heterodimerization inactivates the SSTR3 receptor function.

Somatostatin 14 and -28 receptors. This receptor is coupled through the inhibitory effect of pertussis toxin-sensitive G protein on adenosine cyclase. In addition, it stimulates phosphotyrosine phosphatase and PLC through pertussis toxin-insensitive and sensitive G protein. By inhibiting voltage-dependent calcium channels to inhibit calcium entry. As a functionally dominant somatostatin receptor, it mediates the inhibitory effect of somatostatin-14 on hormone secretion in pancreatic-and-cells. It inhibits cell growth by enhancing phosphorylation of MAPK1 and MAPK2 and subsequent upregulation of CDKN1B. Stimulate neuron migration and axon growth, which may be involved in neuron development and maturation during brain development. PTPN6 mediates the negative regulation of insulin receptor signaling. Heterodimerization inactivates the SSTR3 receptor function.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1312ZP

Humanized

Human

The antibody that specifically bind to the extracellular loop 2 (ecl2) of human somatostatin receptor (hSSTR) are used for diagnosing and treating various indications, including cancer and carcinoid syndrome.

Cancer

Cancer