Full Name
heat shock 27kDa protein 1
Background
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
Alternative Names
HSPB1; heat shock 27kDa protein 1; CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102; heat shock protein beta-1; HSP 27; 28 kDa heat shock protein; heat shock 27 kDa protein; heat shock 27kD protein 1; stress-responsive protein 27; estrogen-regulated 24 kDa protein; epididymis secretory protein Li 102
Cellular Localization
Cytoskeleton, Nucleus
Involvement in Disease
Diseases associated with HSPB1 include Charcot-Marie-Tooth Disease, Axonal, Type 2F and Neuronopathy, Distal Hereditary Motor, Type Iib.
Related Pathways
Its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR.
Function
Small heat shock protein, as a molecular chaperone that may maintain the denatured protein in a foldable state. It plays a role in stress resistance and actin tissue. Through the activity of its molecular chaperones, many biological processes can be regulated, including neurofilament protein phosphorylation and axonal transport.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1013ZP
Description
This is an antibody that specifically binds to heat shock protein (HSP) 27, used for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia.
Indication
Angiogenesis-dependent Ailment
