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Non-Fucosylated Anti-Human GM2 (ART150) Therapeutic Antibody (CAT#: BioBet-1607ZP) Datasheet

Target
GM2
Isotype
IgG
Description
ADCC-Enhanced anti-GM2 (ART150) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced GM2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GM2
Full Name
ganglioside
Background
GM2 is expressed at high levels of on a variety of tumor cell.
Alternative Names
GM2; ganglioside
Cellular Localization
Lysosome
Involvement in Disease
Diseases associated with GM2A include Gm2-Gangliosidosis, Ab Variant and Tay-Sachs Disease.
Related Pathways
Its related pathways are Lysosome and Innate Immune System.
Function
The large binding pocket can hold several single-chain phospholipids and fatty acids, and GM2A also shows some calcium-independent phospholipase activities (similarities). Binds gangliosides and stimulates the degradation of gangliosides GM2. It only stimulates the breakdown of ganglioside GM2 and glycolipid GA2-hexosaminidase A. It extracts a single GM2 molecule from the membrane and presents it to hexosaminidase A in a soluble form, which cleaves n-acetyl-d-galactosamine and converts it to GM3 (by similarity). Has cholesterol transfer activity.
Post-translational modifications
The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ART150
Host
Humanized
Species Reactivity
Human
Description
The antibody of ART150 which targets ganglioside called GM2 is effective in treating cancer.
Indication
Cancer

Cancer

Related Products

Non-Fucosylated Anti-Human GM2 (BIW-8962) Therapeutic Antibody (CAT#: BioBet-1782ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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