Book a Meeting

Anti-GM2 Antibody, Non-Fucosylated (BioBet-1607ZP) (CAT#: BioBet-1607ZP) Datasheet

Target
GM2
Isotype
IgG
Description
Anti-GM2 Antibody, Non-Fucosylated (BioBet-1607ZP) is a humanized monoclonal IgG antibody against GM2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced GM2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GM2
Full Name
ganglioside
Background
GM2 is expressed at high levels of on a variety of tumor cell.
Alternative Names
GM2; ganglioside
Cellular Localization
Lysosome
Involvement in Disease
Diseases associated with GM2A include Gm2-Gangliosidosis, Ab Variant and Tay-Sachs Disease.
Related Pathways
Its related pathways are Lysosome and Innate Immune System.
Function
The large binding pocket can hold several single-chain phospholipids and fatty acids, and GM2A also shows some calcium-independent phospholipase activities (similarities). Binds gangliosides and stimulates the degradation of gangliosides GM2. It only stimulates the breakdown of ganglioside GM2 and glycolipid GA2-hexosaminidase A. It extracts a single GM2 molecule from the membrane and presents it to hexosaminidase A in a soluble form, which cleaves n-acetyl-d-galactosamine and converts it to GM3 (by similarity). Has cholesterol transfer activity.
Post-translational modifications
The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1607ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody of ART150 which targets ganglioside called GM2 is effective in treating cancer.
Antibody Indication
Cancer

Cancer

Related Products

Anti-GM2 Antibody, Non-Fucosylated (BioBet-1782ZP) (CAT#: BioBet-1782ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.