Non-Fucosylated Anti-Human Gastrin (XPA067. 06) Therapeutic Antibody (CAT#: BioBet-906ZP) Datasheet

GAST

growth associated protein 43

Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17.

GAST; gastrin; GAS; preprogastrin

Extracellular region or secreted

Diseases associated with GAST include Gastritis and Zollinger-Ellison Syndrome.

Its related pathways are Secretion of Hydrochloric Acid in Parietal Cells and RET signaling.

Gastrin stimulates the gastric mucosa to produce and secrete hydrochloric acid, and the pancreas secretes digestive enzymes. It can also stimulate smooth muscle contraction, increase blood circulation and water secretion in the stomach and intestines.

Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

XPA067. 06

Human

Human

XPA067. 06 is an affinity matured, fully human anti-gastrin monoclonal antibody that was generated. The antibody was tested in a mouse gastric pH model to determine its effect on acid secretion. The results demonstrate that XPA067. 06 effectively binds and neutralizes human gastrin-17 in vivo with rapid onset and prolonged duration of efficacy.

Cancer

Cancer