Non-Fucosylated Anti-Human FZD7 (18R8) Therapeutic Antibody (CAT#: BioBet-1443ZP) Datasheet

FZD7

Frizzled-7

Frizzled-7 is a protein that in humans is encoded by the FZD7 gene.

FZD7, FzE3, frizzled class receptor 7

Plasma membrane, Endosome

Diseases associated with FZD7 include Exudative Vitreoretinopathy and Gastric Cancer.

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.

Wnt protein receptor. Most frizzled protein receptors bind to the typical signaling pathway of -catenin, leading to the activation of scatter proteins, the inhibition of GSK-3 kinase, the nuclear accumulation of -catenin, and the activation of Wnt target genes. A second signaling pathway involving PKC and calcium flux has been found in some family members, but it is not clear whether it represents a unique pathway or whether it can be integrated into the canonical pathway because of Wnt-mediated GSK-3 Kinase inactivation seems to require PKC. Both of these pathways seem to involve interaction with protein g. Activation of WNT8 induces the expression (by similarity) of catenin target genes. After the ligand is activated, it binds to CCDC88C/DAPLE and replaces DVL1 from FZD7, resulting in inhibition of canonical Wnt signaling. CCDC88C activates g protein and triggers an atypical Wnt response. May be involved in the formation of tissue morphology and/or the transduction and cell-to-cell transmission of polar information in differentiated tissues

Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

18R8

Human

Human

The antibody binds to human frizzled receptor and confirmed to inhibit Wnt signaling and/or inhibit tumor growth.

Cancer

Cancer