Non-Fucosylated Anti-Human FZD2 (18R8) Therapeutic Antibody (CAT#: BioBet-1437ZP) Datasheet

FZD2

Frizzled-2

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.

FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2

Plasma membrane

Diseases associated with FZD2 include Omodysplasia 2 and Robinow Syndrome, Autosomal Dominant 2.

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Association Between Physico-Chemical Features and Toxicity Associated Pathways.

Wnt protein receptor. Most frizzled protein receptors bind to the typical signaling pathway of -catenin, leading to the activation of scatter proteins, the inhibition of GSK-3 kinase, the nuclear accumulation of -catenin, and the activation of Wnt target genes (PubMed: 25759469). A second signaling pathway involving PKC and calcium flux has been found in some family members, but it is not clear whether it represents a unique pathway or whether it can be integrated into the canonical pathway because of Wnt-mediated GSK-3 Kinase inactivation seems to require PKC. Both of these pathways seem to involve interaction with protein g. It may be involved in the formation of tissue morphology and/or the transduction of polarity information and cell-to-cell transmission in differentiated tissues.

Cancer antibody; Developmental Biology antibody; Signaling Transduction antibody

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

18R8

Human

Human

The antibody binds to human frizzled receptor and confirmed to inhibit Wnt signaling and/or inhibit tumor growth.

Cancer

Cancer